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A house on Peisley Street at the centre of a siege has been flood lit has Orange Police's endeavours to end what is now a long-running saga stretch into the night.

As it stands at 7pm, multiple police crews have approached a house on Peisley Street, where a man is believed to be holed-up inside, only to retreat moments later.

Orange police are advising people to avoid the northern end of Peisley Street with armed officers on the scene, however, a crowd of around 25 people remains at the location.

There's around five police cars at the location, which is on the Peisley Street block bound by Matthews Avenue and Margaret Street.

NSW Highway Patrol cars have blocked both intersections with Peisley Street as police officers attempt to negotiate with the man.

Central West Police District officers have been at the property since around 9.30am, on Tuesday, September 20.

It's unknown if there are other people inside the home.

The street, which is a main arterial road to north Orange, has been cut off since around 10.45am.

Earlier on in the day, witnesses said a person appeared to be inside a house and a negotiator was on the scene as well.

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